diff --git a/BioArchLinux/r-deseq2/PKGBUILD b/BioArchLinux/r-deseq2/PKGBUILD
index f9105d7b43..9864416a01 100644
--- a/BioArchLinux/r-deseq2/PKGBUILD
+++ b/BioArchLinux/r-deseq2/PKGBUILD
@@ -1,9 +1,9 @@
 # Maintainer: Guoyi Zhang <guoyizhang at malacology dot net>
 
 _pkgname=DESeq2
-_pkgver=1.44.0
+_pkgver=1.46.0
 pkgname=r-${_pkgname,,}
-pkgver=1.44.0
+pkgver=1.46.0
 pkgrel=1
 pkgdesc='Differential gene expression analysis based on the negative binomial distribution'
 arch=('x86_64')
@@ -45,7 +45,7 @@ optdepends=(
   r-vsn
 )
 source=("https://bioconductor.org/packages/release/bioc/src/contrib/${_pkgname}_${_pkgver}.tar.gz")
-sha256sums=('b6b1f0e1d1c626196220e8d8238a71bde6aa36e227b54461ffb01cb6fadcf1c8')
+sha256sums=('abf33acf09ac80bf82b546ac9e46e980e951e1cf7a04df2dea49b78cd0c00c58')
 
 build() {
   R CMD INSTALL ${_pkgname}_${_pkgver}.tar.gz -l "${srcdir}"